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Direx News Scam

May 18 2021

Direx News Scam

Generic Name:caffeine / magnesium salicylate

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  • Side Effects

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Note: This document contains side effect information about caffeine / magnesium salicylate. Some of the dosage forms listed on this page may not apply to the brand name Diurex.

Applies to caffeine/magnesium salicylate: oral tablet

Nervous system

Nervous system side effects associated with caffeine consumption have included central nervous system stimulation such as irritability, restlessness, and jitteriness. Tinnitus and subjective hearing loss (or both) may occur with salicylate. Some investigators have reported that modest doses may result in decreased frequency selectivity and may therefore impair hearing performance, particularly in the setting of background noise.[Ref]

Gastrointestinal

Gastrointestinal side effects of both caffeine and salicylate have included epigastric distress, abdominal discomfort or pain, nausea, and vomiting.[Ref]

Other

Other side effects have included Reye's syndrome with salicylate use in children with an acute viral illness. Reye's syndrome has also been reported even more rarely in adults.[Ref]

Cardiovascular

Cardiovascular side effects associated with caffeine products have rarely included tachycardia, increased left ventricular output, and increased stroke volume.[Ref]

General

In general, consumption of higher doses of caffeine (less than 600 mg/day) has been reported to have lead to caffeinism. Caffeinism is a syndrome characterized by anxiety, restlessness, and sleep disorders (similar to anxiety states). It has also been reported that chronic, heavy caffeine ingestion may be associated with depression. Caffeine may cause anxiety and panic in panic disorder patients and may aggravate premenstrual syndrome (PMS).[Ref]

Renal

Renal side effects associated with caffeine consumption have included increased urine flow rate, creatinine clearance, and sodium and calcium excretion.[Ref]

Respiratory

Respiratory side effects of salicylates have included bronchospastic reactions. Nonacetylated salicylates rarely cause reactions even in susceptible people when very large doses are given.

Hypersensitivity

Hypersensitivity side effects of magnesium salicylate include severe allergic reactions which may include hives, facial swelling, asthma, and shock.

References

1. 'Product Information. Cafcit (caffeine)' Roxane Laboratories Inc, Columbus, OH.

2. Boettcher FA, Salvi RJ 'Salicylate ototoxicity: review and synthesis.' Am J Otolaryngol 12 (1991): 33-47

3. Thomas J, Straus WL, Bloom BS 'Over-the-counter nonsteroidal anti-inflammatory drugs and risk of gastrointestinal symptoms.' Am J Gastroenterol 97 (2002): 2215-9

4. Lanas A, Serrano P, Bajador E, Esteva F, Benito R, Sainz R 'Evidence of aspirin use in both upper and lower gastrointestinal perforation.' Gastroenterology 112 (1997): 683-9

5. 'Product Information. Bayer aspirin (aspirin).' Bayer, West Haven, CT.

6. Belay ED, Bresee JS, Holman RC, Khan AS, Shahriari A, Schonberger LB 'Reye's syndrome in the United States from 1981 through 1997.' N Engl J Med 340 (1999): 1377-82

7. Sondermeijer H, van Marle A, Kamen P, Krum H 'Acute effects of caffeine on heart rate variability.' Am J Cardiol 90 (2002): 906

8. Hartley TR, Lovallo WR, Whitsett TL 'Cardiovascular effects of caffeine in men and women.' Am J Cardiol 93 (2004): 1022-6

9. Sawynok J 'Pharmacological rationale for the clinical use of caffeine.' Drugs 49 (1995): 37-50

10. Clementz GL, Dailey JW 'Psychotropic effects of caffeine.' Am Fam Physician 37 (1988): 167-72

More about Diurex (caffeine / magnesium salicylate)

Other Formulations

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

What is DirectX?

DirectX is a set of components in Windows that allows software, primarily and especially games, to work directly with your video and audio hardware. Games that use DirectX can use multimedia accelerator features built-in to your hardware more efficiently which improves your overall multimedia experience.

Check which version of DirectX is installed

The DxDiag tool reports detailed information about the DirectX components and drivers installed on your system and can be used.

Windows 10

  1. From Start, type dxdiag in the Search box, and then press enter.

  2. Tap or click on dxdiag from the results.

  3. Check DirectX Version on the first page of the report in the System Information section.

Windows 8.1 or 8

  1. Swipe in from the right edge of the screen, and then tap Search. Type dxdiag in the search box. Or, just type dxdiag from Start.

  2. Tap or click on dxdiag from the results.

  3. Check DirectX Version on the first page of the report in the System Information section.

Windows 7 or earlier

  1. Click Start, type dxdiag in the search box.

  2. Tap or click on dxdiag from the results.

  3. Check DirectX Version on the first page of the report in the System Information section.

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DirectX versions and updates by Operating System

Windows 10 and Server 2016 Technical Preview

DirectX 11.3 and 12 are included with these Windows versions.

Updates will be available through Windows Update. There is no stand-alone package for these versions of DirectX.

Windows 8, RT, 8.1, Server 2012, and Server 2012 R2

  • DirectX 11.1 is included in Windows 8, Windows RT, and Windows Server 2012. There is no stand-alone update package for DirectX 11.1. You can only install this DirectX version through Windows Update in Windows 8, Windows RT and Windows Server 2012.

  • DirectX 11.2 is included in Windows 8.1, Windows RT 8.1 and Windows Server 2012 R2. There is no stand-alone update package for DirectX 11.2. You can only install this DirectX version through Windows Update in Windows 8.1, Windows RT 8.1 and Windows Server 2012 R2.

Note To upgrade DirectX further, you will need to upgrade your operating system.

Windows 7 and Server 2008 R2

  • DirectX 11.0 is included in Windows 7 and Server 2008 R2. There is no stand-alone update package for this version. You can update DirectX by installing the service pack and update listed below.

  • DirectX 11.1 is available for Windows 7 SP1 and Windows Server 2008 RS SP1, with Platform Update for Windows 7 and Windows Server 2008 (KB2670838).

Note To upgrade DirectX further, you will need to upgrade your operating system.

Windows Vista and Windows Server 2008

  • DirectX 10 is included in Windows Vista. There is no stand-alone update package for this version. You can update DirectX by installing the service pack and update listed below.

  • DirectX 10.1 is included in Windows Vista SP1 or later, and Windows Server SP1 or later. There is no stand-alone update package for this version. You can update DirectX by installing the service pack and update listed below.

  • DirectX 11.0 is available for Windows Vista SP2 and Windows Server 2008 SP2, with KB971512 installed.

Note To upgrade DirectX further, you will need to upgrade your operating system.

Windows XP and Windows Server 2003

DirectX 9.0c is available for Windows XP and Windows Server 2003 by installing the DirectX 9.0c End-User Runtime.

Some applications and games require DirectX 9. However, your computer includes a more recent version of DirectX. If you install and then run an application or game that requires DirectX 9, you might receive an error message such as 'The program can't start because d3dx9_35.dll is missing from your computer. Try reinstalling the program to fix this problem.'

To resolve this issue, install DirectX End-User Runtime.

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Notes

  • When you run this package, no change is made to your version of DirectX, Direct3D 9, Direct3D 10.x, Direct3D 11.x, DirectInput, DirectSound, DirectPlay, DirectShow, or DirectMusic.

  • To upgrade DirectX further, you will need to upgrade your operating system.

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